rho-selective guanine exchange factor akap13 mediates stress fiber formation
| PAG Title | rho-selective guanine exchange factor akap13 mediates stress fiber formation |
| PAG ID | WAG000016 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The A-kise anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kise A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP13 is a splice variant of the oncogene Lbc. Altertive splicing of the AKAP13 gene results in at least 3 transcript variants encoding different isoforms containing a Dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the ictive GTPase to the active form capable of transducing sigls. The PH domain has multiple functions. These splice variants contain a fragment that was origilly identified as Ht31 (See Carr et al 1991) which acts as a scaffolding protein to regulate the Rho sigling pathway and as protein kise A-anchoring protein creating a coordition of these two siglling pathways. |
| Species | Homo sapiens |
| nCoCo Score | 1,160 |
| Base PAG ID | WAG000016 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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